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Following an initial period of vigorous activity, the mice adopt a characteristic immobile posture and no longer attempt to escape. Therefore, the present study was conducted to investigate the effect of sympathetic antagonists on the proposed antidepressant action of alprazolam in mice subjected to the behavior despair method.
The onset of immobility was recorded during the last four minutes of the six-minute testing period; mice were judged immobile when they floated in an upright position and made only small movements to keep their head above water. If Alexza chooses not to exercise the purchase option, Symphony Allegro retains the rights to the product candidates.
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